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Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it.
The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

• Sales Rank: #1016581 in Books
• Published on: 2016-12-12
• Original language: English
• Dimensions: 9.60" h x .60" w x 6.80" l, .0 pounds
• Binding: Paperback
• 360 pages

From the Back Cover
Cancer, which has become the second-most prevalent health issue globally, is essentially resulting from a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow a cancer to thrive - and how these networks can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors tell a compelling story of how cancer works at the molecular level, and how targeted therapies - using kinase inhibitors and other modulators of signaling pathways - can contain and eventually cure it.
The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their functions in healthy versus cancer cells. Coloured figures and the text which is written in plain style make the complex topic easy to understand. Specially prepared teaching videos on key concepts and pathways in cancer signaling illustrate the most relevant aspects. They are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

About the Author
Christoph Wagener is Professor of Clinical Biochemistry and former director of the Institute of Clinical Chemistry at the University Medical Center Hamburg-Eppendorf, Germany. His areas of research are the interaction of tumor cells with their microenvironment, and molecular approaches to tumor diagnosis. Professor Wagener has authored more than 100 original scientific publications, 15 scientific reviews and 13 book chapters. Together with Oliver M�ller, he published the text book 'Molekulare Onkologie' and the 'Onkoview Videos', which can be viewed on YouTube. Book and videos have received excellent reviews from readers and viewers.

Carol Stocking is Head of the Research Group Retroviral Pathogenesis at the Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology in Hamburg, Germany. She is a highly regarded expert in the field of leukemogenesis and hematology. Her areas of research are gene regulation, molecular control of differentiation, and hematopoietic stem cells. Dr. Stocking has authored more than 120 original publications in top international journals and 20 book chapters.

Oliver M�ller is Professor for Applied Life Sciences at the University for Applied Sciences Kaiserslautern, Germany. He holds academic degrees in both biochemistry and medicine. His areas of research are the intracellular signal transduction and the genes and proteins involved in carcinogenesis. Professor M�ller is author of more than 80 original articles, 11 patents, 15 scientific reviews and 4 book chapters. His work was honoured by several science awards.

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[K340.Ebook] Fee Download Needlework Antique Flowers, by Elizabeth Bradley

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Needlework Antique Flowers, by Elizabeth Bradley

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A romantic collection of 25 floral needlework projects from the author of Decorative Victorian Needlework. Inspired by actual perennial favorites and heirloom flowers, Bradley accurately charts old roses, pansies, tulips, lilies, snowdrops, poppies, peonies, and cheerful sunflowers. Brilliant color photographs shot on location in Provence highlight the timeless charm of these needlework designs. Full-color photographs.

• Sales Rank: #576098 in Books
• Published on: 1993-08-24
• Released on: 1993-08-24
• Original language: English
• Number of items: 1
• Dimensions: 11.75" h x 10.50" w x .75" l,
• Binding: Hardcover

From the Inside Flap
A romantic collection of 25 floral needlework projects from the author of Decorative Victorian Needlework. Inspired by actual perennial favorites and heirloom flowers, Bradley accurately charts old roses, pansies, tulips, lilies, snowdrops, poppies, peonies, and cheerful sunflowers. Brilliant color photographs shot on location in Provence highlight the timeless charm of these needlework designs. Full-color photographs.

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63 of 63 people found the following review helpful.
My favorite needlepoint book
By drdebs
I love this book! I have about 19 needlepoint books, but this is the one I go back to again and again. For those of you who have only worked with kits and lusted after the VERY EXPENSIVE Elizabeth Bradley kits, this is the way to go. If you are a cross-stitcher, the added plus is that Bradley advocates a cross-stitch because it makes the cushions more durable, it doesn't distort the canvas, and it's what many Victorian needleworkers did.
Elizabeth Bradley patterns are great to take with you on holidays, because you don't need a frame (as long as you use cross-stitch). The colors are beautiful, soft "Antique" English colors. Many of the patterns have a striking black background, and she gives guidance regarding color substitutions (both the sage green and pale blue work well). I've done a number of the patterns, and whenever I'm making a gift I do something from this book.
As the title suggests, the patterns are floral but there is a great deal of variety from striking lilies to Victorian wreaths.

0 of 0 people found the following review helpful.
Five Stars
By Sandra J. Claar
Great book

4 of 4 people found the following review helpful.
A beautiful pattern book that left me wanting more
By SkeinJane
A beautiful collection of Victorian needlework--a little of everything! Floral bouquets, individual flowers, plaids, cherubs, samplers and patchworks. Quite a variety. All vintage, all gorgeous. Not a lot of instructions for the beginner, but lots of photos of completed designs used in creative ways. Ms. Bradley thoughtfully photographs her work done two ways--completed with a light colored background and dark background. The same pattern looks completely different and causes me to be conflicted--I want to make everything in the book (which is simply not practical!)It is divided into designs for all four seasons. A nice book for any needleworkers collection.

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[D626.Ebook] Get Free Ebook An Introduction to Molecular Ecology, by Trevor Beebee, Graham Rowe

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How do we know whether a particular species is monogamous or promiscuous? How can we monitor the illegal trafficking of wildlife? How can we differentiate between the many similar species making up a microbial community? An Introduction to Molecular Ecology introduces the latest molecular concepts and techniques, demonstrating how genetic markers and molecular tools can be used to answer such ecological questions. Such questions, whose answers were previously out of our reach, can now be probed, thereby revolutionizing our understanding of ecological systems and phenomena.

Blending conceptual detail with the most instructive examples, An Introduction to Molecular Ecology is an ideal resource for those new to the subject needing to develop a strong working understanding of the field. The book captures the broad scope of the subject, exploring the use of molecular tools in the context of topics including behavioral genetics, phylogeography, microbial ecology, and conservation.

Features


� Demonstrates the power of molecular ecology as a research tool in a style ideally suited for an undergraduate audience


� Uses practical examples to demonstrate the latest methods and concepts rather than relying exclusively on theoretical models


� Blends factual content with tools for active learning

• Sales Rank: #1345161 in Books
• Published on: 2008-01-10
• Original language: English
• Number of items: 1
• Dimensions: 7.40" h x .90" w x 9.60" l, .62 pounds
• Binding: Paperback
• 416 pages

Review

"I would like to congratulate the authors for providing such a good textbook in introductory molecular ecology. Molecular ecology is an emerging interdisciplinary field with a great potential for future growth. Writing a textbook in such a field is a daunting task and the authors did an overall excellent job."--Dr. Jianping Xu, McMaster University, Canada

"It was exactly what I was looking for: a short but well written introduction to the topic."--Stacey L. Lance, Colby College

"This text has filled the need for a comprehensive introductory text in molecular ecology. The topics covered are of great interest to students in biology, and the authors have done an excellent job of illustrating the concepts with examples from the primary research literature that represent well the taxonomic diversity of molecular ecological studies."--Keith Karoly, Reed College

About the Author
Dr Graham Rowe is a Postdoctoral Researcher in the School of Biological Sciences, University of Sussex.

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0 of 1 people found the following review helpful.
Tedious
By J. Forson
I needed the textbook for school. I found it an interesting read in some chapters. I have not finished reading the entire book but I will get there one day.

0 of 2 people found the following review helpful.
Great overview
By J. Adams
I found this to be a good mix of both evolution and molecular techniques to quantify ecology. Good read.

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[Z917.Ebook] PDF Ebook Life-Cycle Costing: Using Activity-Based Costing and Monte Carlo Methods to Manage Future Costs and Risks, by Jan Emblemsvag

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• Published on: 2003-02
• Format: Import
• Binding: Unbound

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• Sales Rank: #637132 in eBooks
• Published on: 2012-07-30
• Released on: 2012-07-30
• Format: Kindle eBook

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0 of 0 people found the following review helpful.
Recommended for anyone interested in child-centered education
By Mark and Amanda Sanders
I absolutely loved this book! I have bought many books on education throughout the years and this is the first time that I felt compelled to write an Amazon review for one. If you are looking for an alternative outlook on education that is wholly centered on the child and their development as a human, this is the book. Great read!

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Not an academic work, but a good introduction to a vital movement in education. I recommend it for the $10 I paid.

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• Sales Rank: #4551105 in Books
• Published on: 2009
• Binding: Paperback
• 116 pages

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Beautifully Detailed Book
By Janetje Montgomery
Absolutely fantastic! Firstly, it is not a booklet, it is a thick, soft cover book, filled to the brim with Concept Art, pictures, and the Scientist's journal in his handwriting, along with his sketches. There's also a bit of commentary on the creation of the movie. I'm especially happy that my 'used' book's wear was nearly invisible, making it a great deal for me! All in all, an excellent choice for Stitchpunk fans or movie buffs!

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• Sales Rank: #4342497 in Books
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• Sales Rank: #184745 in Books
• Published on: 2014-01-27
• Original language: English
• Number of items: 1
• Dimensions: 9.29" h x 1.09" w x 6.30" l, 1.22 pounds
• Binding: Hardcover
• 304 pages

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Working undercover overseas is the furthest thing from Roy Mancini's mind. Then he responds to a “classified ad from heaven,” seeking someone to set up and run a new office in Asia. At last this mysterious client is revealed to be The Institute, a human intelligence (humint) task force that reports to the Joint Chiefs of Staff. After The Institute hires Roy and trains him in the craft of espionage, he moves to Southeast Asia where he lives under deep cover as a coffee bean trader. Following the recruitment of a clandestine agent from the island of Bali employed as the radio operator on a cargo ship chartered to North Korea, Roy befriends Sasha Popov, a Russian shipping executive, bon vivant, and jazz pianist. Popov is in fact a senior KGB officer whom Roy skillfully manipulates and recruits, driving him to reveal secret information about KGB covert operations.
 As dots are connected, the confluence of intelligence provided by the Balinese agent and the Russian “mole” leads to the discovery of a potentially deadly international conspiracy—and leaves Roy Mancini to prevent a terrorist plot of catastrophic proportions.

• Sales Rank: #1475483 in Books
• Published on: 2015-07-30
• Original language: English
• Number of items: 1
• Dimensions: 8.50" h x .86" w x 5.50" l, .96 pounds
• Binding: Paperback
• 342 pages

About the Author
Stanton Swafford was born in Los Angeles and grew up along the beaches of Southern California. He attended the University of Colorado and the University of the Philippines, where he majored in economics and Asian Studies. He speaks Indonesian, Tagalog, and Mandarin Chinese. Stanton served aboard submarines in the United States Navy during the Cold War era, one of which was the USS Nautilus, the world’s first nuclear submarine. During his period living, working, and playing in Southeast Asia—in the Philippines, Singapore, Malacca, Malaysia, and Bali, Indonesia—he operated undercover as an intelligence officer, ran a timber export company, and performed throughout the region as a jazz musician. His debut novel, China Sea, portrays a plot and settings derived from that experience. Stanton is an avid tennis player and sailor, as well as a self-taught musician who continues to play piano and lead his jazz band. He lives in Southern California with his wife and son, Louie.

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0 of 0 people found the following review helpful.
Excellent first novel - "Thriller"!
By Diane C Wilson
China Sea is a good first novel that moves quickly. Stanton Swafford smoothly develops his characters and it is interesting to see how Roy Mancini makes good use of his background and talents to successfully navigate the world of espionage. The sense of danger underlies the action as Roy finds a way to work with “suspicious” characters in order to fulfill his mission. I enjoyed the descriptions of the Southeast Asia cities and the local cultures. Roy used his knowledge of the ethnic and religious customs to enable him to move around somewhat safely and he used his ability to speak the Indonesian language to increase his chances of success.

Malacca feels like a special place and Stanton Swafford shares the atmosphere of the local settings in such a way that you understand why Roy Mancini enjoys his journey as he travels to accomplish his mission. Roy makes use of his musical talents especially when he takes on the challenge of recruiting Sasha Popov. Sasha is especially dangerous but Roy is up to the toughness required of him. He is also a good judge of character which helped him survive in this tough milieu.

I would recommend this book to those who like a good thriller with elements of danger and relish the cultural tidbits that are sprinkled throughout the story. Sex and violence give the story reality and add to the tale. If you like sailing and music, you will enjoy how the author uses them to add depth to the action. The author’s background gives his story atmosphere and clever twists. I look forward to the next book.

0 of 0 people found the following review helpful.
the exquisite hotels like Raffles in Singapore
By robyn s merino
China Sea was a thoroughly delightful read. The descriptions of various Asian places-- Manila, Malacca,Hong Kong, Singapore, Bali; the exquisite hotels like Raffles in Singapore, the tennis and yacht clubs, the jazz clubs were colorful. The development of the character also showed real life people doing all sorts of activities. The protagonist, Roy Mancini, is multi-talented-- setting up a spy network in multiple places of Asia, playing a hard game of tennis, showing his sailboat racing skills, his jazz trumpet blowing and his ability to engage with people. The plot moves from place to place as Roy sets up his naval spying network. He interacts with all kinds of people as the plot marches along.
It's an entirely enjoyable read. I look forward to a sequel!

0 of 0 people found the following review helpful.
Hard to put down
By Akira Tsurukame
It was fun and very enjoyable. I hardly could put down once I started to read. I kept reading to the next chapter, then to the next chapter. As I did not want to end the fun and enjoyment too soon, I stopped reading before the last chapter. I waited two days and finished the last chapter. I am already waiting for the next serial where the hero Roy Mancini will show us another brilliant espionage activity. The colorful combination of beautiful blue skies and soft breeze of oceans from San Francisco, Panama Canal, Philippines, Hong Kong to Singapore, Malacca and Bali and the clandestine espionage activities between US and Russia and the terrorist group was simply superb and exciting.

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• Sales Rank: #8287500 in Books
• Published on: 1960
• Binding: Paperback

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• Sales Rank: #6795160 in Books
• Binding: Hardcover

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[M682.Ebook] Ebook Sugar Free: 8 Weeks to Freedom from Sugar and Carb Addiction, by Karen Thomson

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Are you a sugar addict? Do you crave sweet treats, bread, pasta and sauce-laden food? Do you experience lethargy and mood swings as a result of blood glucose spikes and dips? Does your weight seesaw unmanageably?

If the answer is yes to any of these questions, your health is at risk. Where fat used to be the enemy, scientists now point to the huge amount of sugar we consume as making us unhealthy.

Sugar Free is packed with recent scientific research and nutritional advice to help you understand addiction to sugar and carbohydrates, including a chapter by Dr Nicole Avena, research neuroscientist, author and expert in nutrition, diet and addiction. It provides eight weeks of meal plans, both vegetarian and non-vegetarian, by nutritionist Emily Macguire, and includes journal exercises to help you break free from the mental, physical and emotional traps of old eating patterns.

Sugar Free shows the way to a sustainable sugar-free lifestyle. Its simple and effective eight-week programme to quit sugar will enable you and your family to enjoy dramatically improved health, increased energy levels and weight loss.

Author Karen Thomson is living in recovery from addiction to sugar and carbohydrates so has been there and understands exactly what you need to know to break the cycle of addiction and find your way to radically improved health.

• Sales Rank: #718274 in Books
• Published on: 2016-08-09
• Released on: 2016-08-09
• Original language: English
• Number of items: 1
• Dimensions: 9.13" h x .75" w x 6.13" l, .0 pounds
• Binding: Paperback
• 224 pages

Review
This book is a testament to a sugar-free enjoyment of food, life, health and happiness

About the Author
Karen Thomson is the founder of the Harmony Eating & Lifestyle Program (HELP, helpdiet.co.za), the world's first in-patient program treating carbohydrate and sugar as an addiction. She started the program with Professor Tim Noakes, dietician Rael Koping and the Harmony Addictions Clinic. She also has an online program called The Sugar Free Revolution.

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1 of 1 people found the following review helpful.
Great, useful information, clearly-presented.
By MikeM
A great book that clarifies much-needed dietary information that will help many people

0 of 0 people found the following review helpful.
Excellent read, cover to cover in one sitting!
By Pam Heiberg
Don't know why it has taken me so long to read this book. So many practical tips and ideas. I always thought I was addicted to sugar, I now know I am!

1 of 1 people found the following review helpful.
Five Stars
By Ilse van der Merwe
Very insightful.

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